Glioblastoma (GBM) is a deadly and debilitating brain tumor with an abysmal prognosis. The
standard therapy for GBM is surgery followed by radiation and chemotherapy with
Temozolomide (TMZ). Treatment of GBMs remains a challenge, largely because of the fast
degradation of TMZ, the inability to deliver an effective dose of TMZ to tumors, and a lack of
target specificity that may cause systemic toxicity. Here, we present a simple method for
synthesizing a nanoparticle-based carrier that can protect TMZ from rapid degradation in …