Purpose To evaluate the efficacy of irradiation of internal mammary nodes (IMN) on 10-year
overall survival in breast cancer patients after mastectomy. Methods and Patients This
multicenter phase 3 study enrolled patients with positive axillary nodes (pN+) or
central/medial tumors with or without pN+. Other inclusion criteria were age< 75 and a
Karnofsky index≥ 70. All patients received postoperative irradiation of the chest wall and
supraclavicular nodes and were randomly assigned to receive IMN irradiation or not …