Testing for antibodies to human aquaporin-4 by ELISA: sensitivity, specificity, and direct comparison with immunohistochemistry
S Jarius, D Franciotta, F Paul, R Bergamaschi… - Journal of the …, 2012 - Elsevier
BACKGROUND: Several assays have been developed to detect antibodies to aquaporin-4
(NMO-IgG/AQP4-Ab). However, many of these assays require sophisticated techniques and
are thus only available at specialized laboratories. This is problematic since NMO-IgG/AQP4-
Ab testing has important prognostic and therapeutic implications. OBJECTIVE: To evaluate a
newly developed, commercial, enzyme-linked immunosorbent assay (ELISA) for detecting
NMO-IgG/AQP4-Ab. METHODS: Serum samples from 261 patients with NMO spectrum …
(NMO-IgG/AQP4-Ab). However, many of these assays require sophisticated techniques and
are thus only available at specialized laboratories. This is problematic since NMO-IgG/AQP4-
Ab testing has important prognostic and therapeutic implications. OBJECTIVE: To evaluate a
newly developed, commercial, enzyme-linked immunosorbent assay (ELISA) for detecting
NMO-IgG/AQP4-Ab. METHODS: Serum samples from 261 patients with NMO spectrum …
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