The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart
DE Logothetis, Y Kurachi, J Galper, EJ Neer… - Nature, 1987 - nature.com
DE Logothetis, Y Kurachi, J Galper, EJ Neer, DE Clapham
Nature, 1987•nature.comSubunits ofguanine nucleotide regulatory proteins purified from bovine cerebral cortex were
used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells.
Single-channel current measurements unexpectedly indicate that the βγ, and not the a
subunits, are responsible for activating the muscarinic-gated potassium channel.
used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells.
Single-channel current measurements unexpectedly indicate that the βγ, and not the a
subunits, are responsible for activating the muscarinic-gated potassium channel.
Abstract
Subunits ofguanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the βγ, and not the a subunits, are responsible for activating the muscarinic-gated potassium channel.
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