[HTML][HTML] The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs
DL van der Velden, LR Hoes, H Van Der Wijngaart… - Nature, 2019 - nature.com
The large-scale genetic profiling of tumours can identify potentially actionable molecular
variants for which approved anticancer drugs are available,–. However, when patients with
such variants are treated with drugs outside of their approved label, successes and failures
of targeted therapy are not systematically collected or shared. We therefore initiated the
Drug Rediscovery protocol, an adaptive, precision-oncology trial that aims to identify signals
of activity in cohorts of patients, with defined tumour types and molecular variants, who are …
variants for which approved anticancer drugs are available,–. However, when patients with
such variants are treated with drugs outside of their approved label, successes and failures
of targeted therapy are not systematically collected or shared. We therefore initiated the
Drug Rediscovery protocol, an adaptive, precision-oncology trial that aims to identify signals
of activity in cohorts of patients, with defined tumour types and molecular variants, who are …
[PDF][PDF] The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs
H van der Wijngaart, DL van der Velden… - Clinical application of …, 2019 - research.vu.nl
The large-scale genetic profiling of tumours can identify potentially actionable molecular
variants for which approved anticancer drugs are available1-3. However, when patients with
such variants are treated with drugs outside of their approved label, successes and failures
of targeted therapy are not systematically collected or shared. We therefore initiated the
Drug Rediscovery protocol, an adaptive, precision-oncology trial that aims to identify signals
of activity in cohorts of patients, with defined tumour types and molecular variants, who are …
variants for which approved anticancer drugs are available1-3. However, when patients with
such variants are treated with drugs outside of their approved label, successes and failures
of targeted therapy are not systematically collected or shared. We therefore initiated the
Drug Rediscovery protocol, an adaptive, precision-oncology trial that aims to identify signals
of activity in cohorts of patients, with defined tumour types and molecular variants, who are …
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