Brain-based learning (BBL) represents a new paradigm for teaching 21st Century learners. This chapter introduces brain-based professional development (BBPD) that utilizes theories and key findings from the field of cognitive neuroscience. This chapter reviews brain-based approach to learning and brain-compatible strategies for teaching as well as how to design a BBL lesson plan. Additionally, the chapter highlights the significance of incorporating BBL in professional development especially for novice English language teachers on shifting English language teachers' pedagogical perceptions. It stresses the importance of educating teachers about the brain and introducing brain-based instructional strategies. Besides, future research directions and educational implications of brain-based instruction are provided particularly for English language teaching and classroom environment.