The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

…, AI Levey, JD Buxbaum, M Ehrlich, S Gandy… - Scientific data, 2018 - nature.com
… from postmortem human brains, the Mayo cohort (doi:10.7303… proteomic profiling as the
Mount Sinai cohort. After filtering those with more than 15% missing values in the proteomic data

Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

ECB Johnson, EK Carter, EB Dammer, DM Duong… - Nature …, 2022 - nature.com
cohorts that also have been profiled using other -omics modalities, including genomics
and transcriptomics… For the Mount Sinai cohort, before TMT labeling the 198 samples were …

[HTML][HTML] Large-scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicity

…, A Vander Linden, W Poehlman, X Chen, S Baheti… - bioRxiv, 2024 - ncbi.nlm.nih.gov
… Integrated analyses of proteomic and transcriptomic data in … In addition, amongst Emory
samples, 26 samples from Mount Sinai … and replication in independent cohorts are warranted to …

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …

…, PL De Jager, DA Bennett, TS Wingo, S Rangaraju… - Nature medicine, 2020 - nature.com
… We validate this protein network in a separate community-based cohort using a different
MS-… is preserved in different brain regions affected in AD. By analyzing a separate cohort of …

[HTML][HTML] Deep multilayer brain proteomics identifies molecular networks in Alzheimer's disease progression

…, K Yu, KK Dey, JM Yarbro, X Han, BM Lutz, S Rao… - Neuron, 2020 - cell.com
Alzheimers disease (AD) displays a long asymptomatic … The altered proteins are validated
in two independent cohorts, … 5xFAD shows a proteomic signature similar to symptomatic AD …

Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets

…, L Ho, A Goate, V Fossati, S Noggle, S Gandy… - Science …, 2021 - science.org
… In this study, we investigate molecular subtypes of AD in the Mount Sinai/JJ … cohort, we
perform cell-type proportion analysis (Materials and Methods) of bulk tissue transcriptomic data

Identification of conserved proteomic networks in neurodegenerative dementia

V Swarup, TS Chang, DM Duong, EB Dammer, J Dai… - Cell reports, 2020 - cell.com
Data-driven analyses are increasingly valued in modern medicine… proteomics and
transcriptomics from over 1,000 post-mortem brains from six cohorts representing Alzheimers

Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease

AM Eteleeb, BC Novotny, CS Tarraga, C Sohn… - PLoS …, 2024 - journals.plos.org
transcriptomic, proteomic, metabolomic, and lipidomic profiles with clinical and neuropathological
data from multiple human AD cohorts. … -seq raw data from The Mount Sinai Brain Bank (…

Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

…, Alzheimer's Disease Neuroimaging … - Alzheimer's & …, 2022 - Wiley Online Library
… , our integrated analysis of large-scale multiomics data in AD … of this study is the lack of an
independent cohort to replicate … Six brain transcriptomic datasets from the Mount Sinai Brain …

Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease

YJ Sung, C Yang, J Norton, M Johnson… - Science translational …, 2023 - science.org
… discovery cohort, we downloaded the mass spectrometry data … ), Mayo Clinic (MAYO), Mount
Sinai Brain Bank (MSBB), and the … , transcriptomics, and metabolomics) can help to better …