The NF-κB Inhibitor, IMD-0354, Affects Immune Gene Expression, Bacterial Microbiota and Trypanosoma cruzi Infection in Rhodnius prolixus Midgut

CS Vieira, OC Moreira, KKS Batista… - Frontiers in …, 2018 - frontiersin.org
Rhodnius prolixus is an insect vector of Trypanosoma cruzi, the causative agent of Chagas
disease in Latin America. Nuclear factor-κ B (NF-κ B) transcription factors (TF) are conserved
components of the innate immune system in several multicellular organisms including
insects. The drug IMD-0354 [N-(3, 5-bis-trifluoromethyl-phenyl)-5-chloro-2-hydroxy-
benzamide] is a selective inhibitor of I κ B kinases. It blocks I κ Bα phosphorylation thus
preventing nuclear translocation of the NF-κ b TF. In humans, NF-κ B is involved in several …

[引用][C] The NF-κB inhibitor, IMD-0354, affects immune gene expression, bacterial microbiota and Trypanosoma cruzi infection in Rhodnius prolixus midgut. Front …

CS Vieira, OC Moreira, KKS Batista, NA Ratcliffe… - 2018
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