The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies
Nature immunology, 2020•nature.com
Natural killer (NK) cells belong to the innate immune system and contribute to protecting the
host through killing of infected, foreign, stressed or transformed cells. Additionally, via
cellular cross-talk, NK cells orchestrate antitumor immune responses. Hence, significant
efforts have been undertaken to exploit the therapeutic properties of NK cells in cancer.
Current strategies in preclinical and clinical development include adoptive transfer
therapies, direct stimulation, recruitment of NK cells into the tumor microenvironment (TME) …
host through killing of infected, foreign, stressed or transformed cells. Additionally, via
cellular cross-talk, NK cells orchestrate antitumor immune responses. Hence, significant
efforts have been undertaken to exploit the therapeutic properties of NK cells in cancer.
Current strategies in preclinical and clinical development include adoptive transfer
therapies, direct stimulation, recruitment of NK cells into the tumor microenvironment (TME) …
Abstract
Natural killer (NK) cells belong to the innate immune system and contribute to protecting the host through killing of infected, foreign, stressed or transformed cells. Additionally, via cellular cross-talk, NK cells orchestrate antitumor immune responses. Hence, significant efforts have been undertaken to exploit the therapeutic properties of NK cells in cancer. Current strategies in preclinical and clinical development include adoptive transfer therapies, direct stimulation, recruitment of NK cells into the tumor microenvironment (TME), blockade of inhibitory receptors that limit NK cell functions, and therapeutic modulation of the TME to enhance antitumor NK cell function. In this Review, we introduce the NK cell–cancer cycle to highlight recent advances in NK cell biology and to discuss the progress and problems of NK cell–based cancer immunotherapies.
nature.com
以上显示的是最相近的搜索结果。 查看全部搜索结果