Role of Sodium‐Calcium Exchanger (Ncx1) in Embryonic Heart Development: A Transgenic Rescue?

SJ Conway, A KRUZYNSKA‐FREJTAG… - Annals of the New …, 2002 - Wiley Online Library
… 2+ homeostasis in early embryonic heart development in mouse. (a) Ventricular Ca 2+
transients in a spontaneously beating heart tube from a Ncx1 lacZ /+ embryo at 9.5 dpc. Caffeine (…

Developmental regulation of Na+/H+exchanger expression in fetal and neonatal mice

CV Rieder, L Fliegel - … Journal of Physiology-Heart and …, 2002 - journals.physiology.org
development, we used transgenic mice expressing a GFP reporter coupled to the mouse Na
+ /H + exchanger … of the upstream elements that are important for expression in mammalian …

Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart

M Reppel, BK Fleischmann, H Reuter… - Cardiovascular …, 2007 - academic.oup.com
development and function demonstrated by the … embryonic death of NCX-null embryos. It
was therefore the aim of our study to identify key functional regulators of the embryonic NCX. …

Na, K-ATPase is essential for embryonic heart development in the zebrafish

X Shu, K Cheng, N Patel, F Chen, E Joseph, HJ Tsai… - 2003 - journals.biologists.com
… function through interaction with the Na + /Ca 2+ exchanger. … in the mouse suggest that
Na,K-ATPase activity is important during embryogenesis, as α1 homozygous mice are embryonic

Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart

S Siedner, M Krüger, M Schroeter… - The Journal of …, 2003 - Wiley Online Library
… , respectively; E19.5 after exchange and Adult after exchange: skinned ventricular fibres …
a crucial role for TnI in Ca 2+ -regulated force development during murine heart development. …

Myocardial function with reduced expression of the sodium-calcium exchanger

MC Jordan, SA Henderson, T Han, MC Fishbein… - Journal of cardiac …, 2010 - Elsevier
… In summary, the 50% reduction of the exchanger in all the myocytes of HG-KO mice is
associated with normal myocardial structure and function at baseline, tolerance to pressure …

Slc26a6: a cardiac chloride–hydroxyl exchanger and predominant chloride–bicarbonate exchanger of the mouse heart

BV Alvarez, DM Kieller, AL Quon… - The Journal of …, 2004 - Wiley Online Library
… anion exchange proteins in mouse heart, by quantitative real time RT-PCR. Bicarbonate–anion
exchangers … Cl − –HCO 3 − and Cl − –OH − exchange activity of SLC26A6 and AE3 were …

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP

D Harzheim, KH Pfeiffer, L Fabritz, E Kremmer… - The EMBO …, 2008 - embopress.org
mice that harbour a single amino‐acid exchange (R669Q) in the CNBD of the HCN4 channel.
This arginine residue is crucial … of mice via homologous recombination in embryonic stem …

Expressional analysis of the cardiac Na–Ca exchanger in rat development and senescence

MU Koban, AFM Moorman, J Holtz… - Cardiovascular …, 1998 - academic.oup.com
Embryos were obtained from pregnant decapitated rats after … We have examined rat cardiac
Na–Ca exchanger mRNA and … spatially during fetal and neonatal cardiac development. The …

Onset of cardiac function during early mouse embryogenesis coincides with entry of primitive erythroblasts into the embryo proper

RP Ji, CKL Phoon, O Aristizábal, KE McGrath… - Circulation …, 2003 - Am Heart Assoc
… time points and basic physiology of the very early mouse embryonic circulation using …
developed in our laboratory that allows in utero study of the embryonic mouse circulation. …