The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK
The hepatitis E virus (HEV) is the causative agent of hepatitis E, an acute form of viral
hepatitis. The biology and pathogenesis of HEV remain poorly understood. We have used in
vitro binding assays to show that the HEV ORF3 protein (pORF3) binds to a number of
cellular signal transduction pathway proteins. This includes the protein tyrosine kinases Src,
Hck, and Fyn, the p85α regulatory subunit of phosphatidylinositol 3-kinase, phospholipase
Cγ, and the adaptor protein Grb2. A yeast two-hybrid assay was used to further confirm the …
hepatitis. The biology and pathogenesis of HEV remain poorly understood. We have used in
vitro binding assays to show that the HEV ORF3 protein (pORF3) binds to a number of
cellular signal transduction pathway proteins. This includes the protein tyrosine kinases Src,
Hck, and Fyn, the p85α regulatory subunit of phosphatidylinositol 3-kinase, phospholipase
Cγ, and the adaptor protein Grb2. A yeast two-hybrid assay was used to further confirm the …
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