… The fact that APC is an integral part of so many different pathways makes it an ideal … the
APC gene translate into changes at the protein level, which in turn contribute to the role of APC …

… due to the mutational loss of the APC C-terminal sequence has been regarded as a critical
event in the initiation of colon cancer, accumulating evidence suggest that APC truncations …

… to the predicted size of full-length APC was detected in all 7 cell lines. In addition, … APC
proteinscorresponding to the product of the known mutated alleles could be detected in 4 of the …

… and unusual interaction between APC and the microtubule cytoskeleton (7). … APC ever
since. We called her at her laboratory at the University of Dundee in Scotland to discuss how APC …

… , the effects of APC mutation on tumorigenic properties remain unexplored. Using the Apc
Min/+ mouse crossed to the … , we measured the apoptotic and proliferative response to APC …

… the APC gene are thought to be early events in the process of colorectal carcinogenesis.
Although the complete function(s) of the APC … been shown that the APC protein interacts with β-…

… The objective of this study was to re-assess the role of APC mutations in the pathogenesis of
… These results as well as the results of the present study suggest that the APC gene is one of …

… article, the tumor suppressor Adenomatous Polyposis Coli (APC) influences a … We will discuss
the use of APC as both a marker for the … Exploring the numerous processes in which APC …

… adenomatous polyposis coli (APC) and DNA mismatch repair (MMR) genes. The focus of
this review is to summarize the functions of APC and MMR gene products in the development …

… of the APC promoter influences APC silencing. Here we examined the influence of APC
methylation on APC expression in tumors with and without LOH at the APC locus. Material and …