Berberine is a pure phenanthren alkaloid isolated from the roots and bark of herbal plants
such as Berberis, Hydrastis canadensis and Coptis chinensis. Berberine has been
established to inhibit the growth of breast cancer cells, but its effects on the drug resistance
and anoikis-resistance of breast cancer cells have yet to be elucidated. Anoikis, or
detachment-induced apoptosis, may prevent cancer progression and metastasis by blocking
signals necessary for survival of localized cancer cells. Resistance to anoikis is regarded as …