The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma

L Di Tommaso, A Destro, JY Seok, E Balladore… - Journal of …, 2009 - Elsevier
BACKGROUND/AIMS: Liver biopsy for hepatocellular carcinoma (HCC) detection is largely
restricted to small hepatocellular lesions, which are often morphologically challenging,
requiring careful distinction between dysplastic nodules (high-grade) and well-differentiated
HCC. METHODS: We investigated the diagnostic accuracy of a panel of markers (HSP70,
GPC3, and GS), previously tested in resection specimens, in a series of liver biopsies of
large regenerative nodules (n= 13), low-grade dysplastic nodules (n= 21), high-grade …
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