… the onset of the aging process and the rate and extent of its progression. Differences in the
manifestations of aging … Functional capacity is a direct measure of the ability of cells, tissues, …

… The objective of this chapter is to outline the evidence that supports the biological … of
cellular senescence as a unifying mechanism of aging, age-related disease, and frailty. …

… medicine, aging research, and oncology are pertinent to the field … of the biology of aging and
cancer with a focus on frailty, … debated the distinction between intrinsic biological aging (so-…

… Until we find the secret to slowing down the biological clock of aging and preventing the …
and other disabilities characteristic of frailty we should start to promote “healthy aging”, based on …

… , calendar age is a popular estimate of the rate of biological aging in daily life. Indeed, as …
Thus, biological aging is heterogeneous and often disproportionate with the amount of time …

… Our understanding of the biological basis of aging, and how that biology can be manipulated
to improve health and longevity, continues to advance at an accelerating pace. This volume…

… model of aging, due in part to their relatively short lifespan and to the … in the biology-of-aging
field is the translation of frailty … Both the frailty index and frailty phenotype approaches have …

… The rate of decline is the same for men and women, but men have a higher initial V o 2 max
than women, which is one of the reasons that women tend to become frail at an earlier age …

… The objectives of this literature review were to (1) synthesize biological processes linked to
frailty … Studies examining biological processes related to frailty in older adults (≥60 years) …

… of frailty studies. To begin to dif ferentiate the biology that underlies frailty from the biology
of specific disease states, we developed a conceptual model of frailty that includes a central …