The prevalence, diversity, and multiplicity of functions of pep tides in the nervous system are
well known. However, we are only now approaching the point at which our knowledge about
the biosynthesis of neuropeptides can provide us with insights into nervous system function,
just as our knowledge of the enzymes involved in the biosynthesis of conventional
neurotransmitters has so effectively done. To this end, we focus our review on one of the
steps in peptide biosynthesis, peptide a-amidation. We summarize information obtained …