The bloodbrain barrier

R Daneman, A Prat - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …

Structure and function of the bloodbrain barrier

NJ Abbott, AAK Patabendige, DEM Dolman… - Neurobiology of …, 2010 - Elsevier
… Although the majority of large blood-borne molecules are physically prevented from entering
the brain by the presence of the bloodbrain barrier and tight junctions, specific and some …

The bloodbrain barrier

B Obermeier, A Verma, RM Ransohoff - Handbook of clinical neurology, 2016 - Elsevier
… We introduce the blood–cerebrospinal fluid barrier and include a brief aside about evolutionary
aspects of barrier formation and refinements. Lastly, since restoration of barrier function …

Development of the blood-brain barrier

W Risau, H Wolburg - Trends in neurosciences, 1990 - cell.com
barriers in the brain. This review focuses on the development of the endothelial blood-brain
barrier. … in the establishment of a functional blood-brain barrier, it is necessary to investigate …

The blood-brain barrier

GW Goldstein, AL Betz - Scientific American, 1986 - JSTOR
In human beings and other complex organisms, life itself depends on homeostasis, the
maintenance of a constant internal milieu. Nowhere is this dependence more pronounced than in …

The bloodbrain barrier: an overview: structure, regulation, and clinical implications

P Ballabh, A Braun, M Nedergaard - Neurobiology of disease, 2004 - Elsevier
The bloodbrain barrier (BBB) is a diffusion barrier, which impedes influx of most compounds
from blood to brain. Three cellular elements of the brain microvasculature compose the …

What is the bloodbrain barrier (not)?

I Bechmann, I Galea, VH Perry - Trends in immunology, 2007 - cell.com
… However, numerous studies in the field suffer from an inappropriate view or understanding
of the bloodbrain barrier (BBB). Terms including ‘leukocytes cross the bloodbrain barrier’ …

Development of the blood-brain barrier

B Engelhardt - Cell and tissue research, 2003 - Springer
… Obviously, these dyes were prevented from gaining access to the blood circulation. The
concept of a vascular blood-brain barrier, which also functions as a brain-blood barrier, was …

The blood-brain barrier

F Dyrna, S Hanske, M Krueger, I Bechmann - Journal of Neuroimmune …, 2013 - Springer
barriers” of the BBB. In this article, we provide an overview of what maintains barrier function
for blood-… solutes is neither mechanistically equal to a barrier for immune cells nor in regard …

The blood-brain barrier

WH Oldendorf - Experimental eye research, 1977 - Elsevier
… B|ood-brain barrier studies in man using the double-indicator method. Am. J. … Selective
vulnerability of blood brain barrier in chemically induced lesions. J. Neuropathol. …