Several drugs can induce the development of aseptic meningitis. Drug-induced aseptic
meningitis (DIAM) can mimic an infectious process as well as meningitides that are
secondary to systemic disorders for which these drugs are used. Thus, DIAM constitutes a
diagnostic and patient management challenge. Cases of DIAM were reviewed through a
MEDLINE literature search (up to June 1998) to identify possible clinical and laboratory
characteristics that would be helpful in distinguishing DIAM from other forms of meningitis or …

Methods| Using the MEDLINE database, we searched the literature to February 2014 and
included those cases with cerebrospinal fluid (CSF) findings and reviews added to the
literature from 1999 to date. Tables have been assembled from information derived from 192
studies (these data are available from the authors on request). Results| Four groups of drugs
continue to be associated with DIAM (Table 1): nonsteroidal anti-inflammatory drugs
(NSAIDs), antibiotics, immunosuppressiveimmunomodulatory (IS-IM), and antiepileptic …