The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus
ME Lund, J To, BA O'Brien, S Donnelly - Journal of immunological methods, 2016 - Elsevier
The human monocytic cell line, THP-1, is the most widely used model for primary human
monocytes/macrophages. This is because, following differentiation using phorbol 12-
myristate 13-acetate (PMA), THP-1 cells acquire a macrophage-like phenotype, which
mimics, in many respects, primary human macrophages. Despite the widespread use of THP-
1 cells in studies elucidating macrophage responses to inflammatory stimuli, as well as the
development and screening of potential therapeutics, there is currently no standardised …
monocytes/macrophages. This is because, following differentiation using phorbol 12-
myristate 13-acetate (PMA), THP-1 cells acquire a macrophage-like phenotype, which
mimics, in many respects, primary human macrophages. Despite the widespread use of THP-
1 cells in studies elucidating macrophage responses to inflammatory stimuli, as well as the
development and screening of potential therapeutics, there is currently no standardised …
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