The combination of CYP3A4* 22 and CYP3A5* 3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation
N Lloberas, L Elens, I Llaudó, A Padullés… - Pharmacogenetics …, 2017 - journals.lww.com
Results EM had an 88% lower dose-adjusted C 0 compared with IM. PM had a 26% higher
dose-adjusted C 0 compared with IM. The percentage of patients with supratherapeutic Tac
exposure (C 0> 15 ng/ml) was significantly higher in PM (43.5%) compared with EM (0%) at
days 5–7 after transplantation (P= 0.01). About 30% of EM had subtherapeutic exposure (C
0< 5 ng/ml) at days 5–7 after transplantation (P= 0.001). Conclusion The combined CYP3A4
and CYP3A5 genotype of renal transplant recipients has a major influence on the Tac dose …
dose-adjusted C 0 compared with IM. The percentage of patients with supratherapeutic Tac
exposure (C 0> 15 ng/ml) was significantly higher in PM (43.5%) compared with EM (0%) at
days 5–7 after transplantation (P= 0.01). About 30% of EM had subtherapeutic exposure (C
0< 5 ng/ml) at days 5–7 after transplantation (P= 0.001). Conclusion The combined CYP3A4
and CYP3A5 genotype of renal transplant recipients has a major influence on the Tac dose …
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