The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial
cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells. Thymic
precursors express both CD8 and CD4, and it has been suggested that the intracellular
signals generated by CD8 or CD4 binding to class I or II MHC, respectively, might influence
the fate of uncommitted cells. Here we test the notion that intracellular signaling by CD4
directs the development of thymocytes to a CD4 lineage. A hybrid protein consisting of the …
cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells. Thymic
precursors express both CD8 and CD4, and it has been suggested that the intracellular
signals generated by CD8 or CD4 binding to class I or II MHC, respectively, might influence
the fate of uncommitted cells. Here we test the notion that intracellular signaling by CD4
directs the development of thymocytes to a CD4 lineage. A hybrid protein consisting of the …
The Cytoplasmic Domain of CD4 Promotes the Development of CD4 Lineage T Cells By Andrea Itano, Patrick Salmon, Dimitris Kioussis,* Mauro Tolaini
P Corbella, E Robey - ncbi.nlm.nih.gov
Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial
cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells. Thymic
precursors express both CD8 and CD4, and it has been suggested that the intracellular
signals generated by CD8 or CD4 binding to class I or II MHC, respectively, might influence
the fate of uncommitted cells. Here we test the notion that intracellular signaling by CD4
directs the development of thymocytes to a CD4 lineage. A hybrid protein consisting of the …
cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells. Thymic
precursors express both CD8 and CD4, and it has been suggested that the intracellular
signals generated by CD8 or CD4 binding to class I or II MHC, respectively, might influence
the fate of uncommitted cells. Here we test the notion that intracellular signaling by CD4
directs the development of thymocytes to a CD4 lineage. A hybrid protein consisting of the …
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