STING (stimulator of interferon genes) is a cytosolic sensor for cyclic dinucleotides and also
an adaptor molecule for intracellular DNA receptors. Although STING has important
functions in the host defense against pathogens and in autoimmune diseases, its
physiological relevance in intestinal homeostasis is largely unknown. In this study, we show
that STING−/− mice presented defective protective mechanisms of intestinal mucosa,
including decreased number of goblet cells, diminished mucus production, and lower levels …