[PDF][PDF] The determination of correlation linkages between level of reactive oxygen species, contents of neutrophiles and blood gas composition in experimental acute …
Georgian medical news, 2016•geomednews.com
Acute lung injury (ALI) remains a major cause of acute respiratory failure and death of
patients. Despite the achievements at the current stage in treatment, morbidity and mortality
of ALI remain high [5, 11]. A recent international epidemiological study ALI showed that the
mortality rate of patients with this syndrome is quite high and is 60, 2% and the percentage
not significantly varies in different parts of the world. In North America lethality from ALI is 52,
5%, Europe–64, 2%, in Latin America–59, 3%[8]. Although the ALI is a heterogeneous …
patients. Despite the achievements at the current stage in treatment, morbidity and mortality
of ALI remain high [5, 11]. A recent international epidemiological study ALI showed that the
mortality rate of patients with this syndrome is quite high and is 60, 2% and the percentage
not significantly varies in different parts of the world. In North America lethality from ALI is 52,
5%, Europe–64, 2%, in Latin America–59, 3%[8]. Although the ALI is a heterogeneous …
Acute lung injury (ALI) remains a major cause of acute respiratory failure and death of patients. Despite the achievements at the current stage in treatment, morbidity and mortality of ALI remain high [5, 11]. A recent international epidemiological study ALI showed that the mortality rate of patients with this syndrome is quite high and is 60, 2% and the percentage not significantly varies in different parts of the world. In North America lethality from ALI is 52, 5%, Europe–64, 2%, in Latin America–59, 3%[8].
Although the ALI is a heterogeneous disease and can be caused by both pulmonary and extrapulmonary etiological factors, they are based on common pathogenic mechanisms: nonspecific inflammatory reaction to the effect of pathogenic factors, sequestration of neutrophils in the lungs, damage of the vessels wall, activation of cytokine system,“oxidative burst”, reduced production and activity of surfactant and others [2, 12, 13]. Current data suggest systemic autoimmune activation in the pathogenesis of
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