Repeated administration of morphine sensitizes animals to the stimulant and rewarding
properties of the drug. It may also alter the expression and function of GABA receptors within
the ventral tegmental area (VTA), a midbrain region that is implicated in morphine action. In
the present study, the effect of activation of GABAB receptor subtypes within the VTA on
morphine-induced incentive sensitization in female Wistar rats (250-300 g) was investigated.
Female rats (n= 8) were chronically implanted with a 21-gauge cannula in the VTA (V= 8.5 …