The effect of celecoxib, a selective COX-2 inhibitor, on liver ischemia/reperfusion-induced oxidative stress in rats
H Ozturk, A Gezici, H Ozturk - Hepatology Research, 2006 - Elsevier
This study examined the effects of celecoxib on hepatic ischemia/reperfusion (I/R) injury in
rats. A total of 40 male Sprague–Dawley rats weighing 190–210g were randomized into 4
groups of 10:(1) controls: data from unmanipulated animals;(2) sham group: rats subjected
to the surgical procedure, except for liver I/R, and given saline;(3) I/R group: rats that
underwent liver ischemia for 1h followed by reperfusion for 45min;(4) I–R/Celecoxib group:
rats pretreated with celecoxib (3mgkg− 1, ip) 40min before liver I/R. Tc-99m sulfur colloid …
rats. A total of 40 male Sprague–Dawley rats weighing 190–210g were randomized into 4
groups of 10:(1) controls: data from unmanipulated animals;(2) sham group: rats subjected
to the surgical procedure, except for liver I/R, and given saline;(3) I/R group: rats that
underwent liver ischemia for 1h followed by reperfusion for 45min;(4) I–R/Celecoxib group:
rats pretreated with celecoxib (3mgkg− 1, ip) 40min before liver I/R. Tc-99m sulfur colloid …
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