The effect of different head movement paradigms on vestibulo-ocular reflex gain and saccadic eye responses in the suppression head impulse test in healthy adult …
D Starkov, B Vermorken, TS Van Dooren… - Frontiers in …, 2021 - frontiersin.org
D Starkov, B Vermorken, TS Van Dooren, L Van Stiphout, M Janssen, M Pleshkov…
Frontiers in neurology, 2021•frontiersin.orgObjective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain)
and saccadic response in the suppression head impulse paradigm (SHIMP) between
predictable and less predictable head movements, in a group of healthy subjects. It was
hypothesized that higher prediction could lead to a lower VOR gain, a shorter saccadic
latency, and higher grouping of saccades. Methods: Sixty-two healthy subjects were tested
using the video head impulse test and SHIMPs in four conditions: active and passive head …
and saccadic response in the suppression head impulse paradigm (SHIMP) between
predictable and less predictable head movements, in a group of healthy subjects. It was
hypothesized that higher prediction could lead to a lower VOR gain, a shorter saccadic
latency, and higher grouping of saccades. Methods: Sixty-two healthy subjects were tested
using the video head impulse test and SHIMPs in four conditions: active and passive head …
Objective: This study aimed to identify differences in vestibulo-ocular reflex gain (VOR gain) and saccadic response in the suppression head impulse paradigm (SHIMP) between predictable and less predictable head movements, in a group of healthy subjects. It was hypothesized that higher prediction could lead to a lower VOR gain, a shorter saccadic latency, and higher grouping of saccades.
Methods: Sixty-two healthy subjects were tested using the video head impulse test and SHIMPs in four conditions: active and passive head movements for both inward and outward directions. VOR gain, latency of the first saccade, and the level of saccade grouping (PR-score) were compared among conditions. Inward and active head movements were considered to be more predictable than outward and passive head movements.
Results: After validation, results of 57 tested subjects were analyzed. Mean VOR gain was significantly lower for inward passive compared with outward passive head impulses (p < 0.001), and it was higher for active compared with passive head impulses (both inward and outward) (p ≤ 0.024). Mean latency of the first saccade was significantly shorter for inward active compared with inward passive (p ≤ 0.001) and for inward passive compared with outward passive head impulses (p = 0.012). Mean PR-score was only significantly higher in active outward than in active inward head impulses (p = 0.004).
Conclusion: For SHIMP, a higher predictability in head movements lowered gain only in passive impulses and shortened latencies of compensatory saccades overall. For active impulses, gain calculation was affected by short-latency compensatory saccades, hindering reliable comparison with gains of passive impulses. Predictability did not substantially influence grouping of compensatory saccades.
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