The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
AB Mayerson, RS Hundal, S Dufour, V Lebon… - Diabetes, 2002 - Am Diabetes Assoc
AB Mayerson, RS Hundal, S Dufour, V Lebon, D Befroy, GW Cline, S Enocksson…
Diabetes, 2002•Am Diabetes AssocWe examined the effect of three months of rosiglitazone treatment (4 mg bid) on whole-body
insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol
release in microdialysis from subcutaneous fat during a two-step (20 and 120 mU· m− 2·
min− 1) hyperinsulinemic-euglycemic clamp in nine type 2 diabetic subjects. In addition, the
effects of rosiglitazone on liver and muscle triglyceride content were assessed by 1H-
nuclear magnetic resonance spectroscopy. Rosiglitazone treatment resulted in a 68%(P< …
insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol
release in microdialysis from subcutaneous fat during a two-step (20 and 120 mU· m− 2·
min− 1) hyperinsulinemic-euglycemic clamp in nine type 2 diabetic subjects. In addition, the
effects of rosiglitazone on liver and muscle triglyceride content were assessed by 1H-
nuclear magnetic resonance spectroscopy. Rosiglitazone treatment resulted in a 68%(P< …
We examined the effect of three months of rosiglitazone treatment (4 mg b.i.d.) on whole-body insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol release in microdialysis from subcutaneous fat during a two-step (20 and 120 mU · m−2 · min−1) hyperinsulinemic-euglycemic clamp in nine type 2 diabetic subjects. In addition, the effects of rosiglitazone on liver and muscle triglyceride content were assessed by 1H-nuclear magnetic resonance spectroscopy. Rosiglitazone treatment resulted in a 68% (P < 0.002) and a 20% (P < 0.016) improvement in insulin-stimulated glucose metabolism during the low- and high- dosage−insulin clamps, respectively, which was associated with ∼40% reductions in plasma fatty acid concentration (P < 0.05) and hepatic triglyceride content (P < 0.05). These changes were associated with a 39% increase in extramyocellular lipid content (P < 0.05) and a 52% increase in the sensitivity of peripheral adipocytes to the inhibitory effects of insulin on lipolysis (P = 0.04). In conclusion, these results support the hypothesis that thiazolidinediones enhance insulin sensitivity in patients with type 2 diabetes by promoting increased insulin sensitivity in peripheral adipocytes, which results in lower plasma fatty acid concentrations and a redistribution of intracellular lipid from insulin responsive organs into peripheral adipocytes.
Am Diabetes Assoc
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