Virtual reality (VR) technology has been widely used in clinical nursing care in recent years. We aimed to systematically evaluate the effect and safety of VR technology on pain control in wound care, to provide evidence and support for clinical wound care. We searched PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, China Biomedical Literature Database, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and Chinese Science and Technology Journal databases for randomised controlled trials (RCTs) on the application of VR technology in wound care up to December 20, 2021. Two researchers independently assessed the quality of the included RCTs and extracted associated data. RevMan5.3 statistical software was used for data analysis. 13 RCTs involving 1258 adult patients were included, of whom 588 patients underwent VR intervention. VR technology intervention could reduce the VAS score(MD = −1.13, 95%CI:−2.01~−0.26, P < .001), pain cognition score(MD = −3.94, 95%CI:−4.59 ~ −3.30, P < .001), pain emotion score(MD = ‐5.21, 95%CI: −10.46 ~ −0.04, P < .001), pain sensation score (MD = −4.94, 95%CI: −9.46 ~ −0.42, P = .03) and blood pressure(MD = −4.66, 95%CI: −8.63 ~ −0.69, P = .02) during would care. There were no significant differences on the heart rate (MD = −1.85, 95%CI: −5.71 ~ −2.01, P = .45) and VR interestingness (MD = 28.96, 95%CI: −22.10 ~ 80.02, P = .27) of the VR group and control group. No publication biases among the synthesised outcomes were found (all P > .001). VR technology can effectively reduce the pain degree and sensation of patients during wound care, which may be an effective auxiliary non‐drug method used for pain relief during wound care.