The enigmatic P450 decarboxylase OleT is capable of, but evolved to frustrate, oxygen rebound chemistry
OleT is a cytochrome P450 enzyme that catalyzes the removal of carbon dioxide from
variable chain length fatty acids to form 1-alkenes. In this work, we examine the binding and
metabolic profile of OleT with shorter chain length (n≤ 12) fatty acids that can form liquid
transportation fuels. Transient kinetics and product analyses confirm that OleT capably
activates hydrogen peroxide with shorter substrates to form the high-valent intermediate
Compound I and largely performs C–C bond scission. However, the enzyme also produces …
variable chain length fatty acids to form 1-alkenes. In this work, we examine the binding and
metabolic profile of OleT with shorter chain length (n≤ 12) fatty acids that can form liquid
transportation fuels. Transient kinetics and product analyses confirm that OleT capably
activates hydrogen peroxide with shorter substrates to form the high-valent intermediate
Compound I and largely performs C–C bond scission. However, the enzyme also produces …
[引用][C] The Enigmatic P450 Decarboxylase OleT Is Capable of, but Evolved To Frustrate, Oxygen Rebound Chemistry
H Xiongyi - 2017
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