The expression of lnc-IL-7R long non-coding RNA dramatically correlated with soluble and membrane-bound isoforms of IL-7Ra gene in multiple sclerosis patients
Neuroscience letters, 2017•Elsevier
Background and purpose Multiple sclerosis (MS) is a neurological disease of the central
nervous system (CNS) that causes physical and cognitive impairments. IL-7Ra is a key non-
MHC gene associated with MS. IL-7Ra is a likely functional candidate for this complex
disease because it is involved in the development, maturation, and homeostasis of T and B
cells. Our aim was to evaluate the expression level and controlling role of lnc-IL-7R in the
expression of two variants of IL-7Ra in MS patients versus healthy controls and their …
nervous system (CNS) that causes physical and cognitive impairments. IL-7Ra is a key non-
MHC gene associated with MS. IL-7Ra is a likely functional candidate for this complex
disease because it is involved in the development, maturation, and homeostasis of T and B
cells. Our aim was to evaluate the expression level and controlling role of lnc-IL-7R in the
expression of two variants of IL-7Ra in MS patients versus healthy controls and their …
Background and purpose
Multiple sclerosis (MS) is a neurological disease of the central nervous system (CNS) that causes physical and cognitive impairments. IL-7Ra is a key non-MHC gene associated with MS. IL-7Ra is a likely functional candidate for this complex disease because it is involved in the development, maturation, and homeostasis of T and B cells. Our aim was to evaluate the expression level and controlling role of lnc-IL-7R in the expression of two variants of IL-7Ra in MS patients versus healthy controls and their correlation with certain clinical features.
Methods
Using the real-time PCR method, we analyzed the expression levels of membrane-bound (IL-7RB) and soluble (IL-7RS) isoforms of IL-7R gene and lnc-IL-7R in 36 MS patients versus 30 healthy controls.
Results
Our results revealed no significant difference between the expression levels of IL-7RB and IL-7RS isoforms of IL-7R gene and lnc-IL-7R in MS patients versus healthy controls (p = 0.7, p = 0.6 and p = 0.8, respectively). Moreover, we found a significant correlation between the expression levels of IL-7RB with lnc-IL-7R, IL-7RS with lnc-IL-7R and IL-7RB with IL-7RS in both patient and control groups.
Conclusions
We have probably uncovered new evidence for the controlling role of long non-coding RNAs in the expression level of genes and their roles in MS.
Elsevier
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