BACKGROUND: The aim of this study was to evaluate the protective effect of melatonin on
ischemia-reperfusion syndrome. METHODS: Thirty-three adult male Wistar albino rats were
randomized into three experimental groups of 11: Group C–control group with no ischemia
or reperfusion. Groups I/R and I/R+ M had 2.5 hours of ischemia and of two hours of
reperfusion by means of clamping of the common femoral artery. All the animals received
maintenance fluid with intraperitoneal (ip) normal saline following general anesthesia. The …

METHODS Thirty-three rats were randomized into three groups of 11: Group C–control
group with no ischemia or reperfusion. Groups I/R and I/R+ M had 2.5 hours of ischemia and
of two hours of reperfusion by means of clamping of the common femoral artery. The animals
of Group I/R+ M were treated with ip Melatonin (10 mg/kg) five minutes before reperfusion. At
the end of reperfusion, samples were taken for histological evaluation and biochemical
analysis. Parameters studied were biopsies of the soleus muscle, level of lactate, creatine …