Telomerase deficiency leads to age-related diseases and shorter lifespans. Inhibition of the
mechanistic target of rapamycin (mTOR) delays aging and age-related pathologies. Here,
we show that telomerase deficient mice with short telomeres (G2-Terc−/−) have an hyper-
activated mTOR pathway with increased levels of phosphorylated ribosomal S6 protein in
liver, skeletal muscle and heart, a target of mTORC1. Transcriptional profiling confirms
mTOR activation in G2-Terc−/− livers. Treatment of G2-Terc−/− mice with rapamycin, an …