As one of the challenges in the organization, Organizational cynicism interacting with occupational burnout, play a decisive role in organizational silence. The purpose of this study is to evaluate the effect of organizational cynicism on organizational silence considering occupational burnout as a mediating variable in the relationship between these two variables. For this purpose, three hypotheses were composed. To collect the information necessary for testing the hypotheses, two standard questionnaires of James (2005) to measure organizational cynicism and occupational burnout, and the questionnaire of Nol and Van Dyke (2012) to measure organizational silence were used and they were distributed Among 189 Employees of Farokhshahr Social Security Hospital as a Sample volume of research. Liserel software was used to analyze the data and hypothesis testing. The results of the test of research hypothesis, confirmed the effect of occupational burnout on organizational silence while showing that there is a significant relationship between organizational cynicism and organizational silence, as well as the occupational burnout, and the effect of occupational burnout is great on this relationship. At the end of the research, some suggestions were also presented in accordance with the findings of the research.