The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
SM Park, AB Gaur, E Lengyel… - Genes & …, 2008 - genesdev.cshlp.org
Cancer progression has similarities with the process of epithelial-to-mesenchymal transition
(EMT) found during embryonic development, during which cells down-regulate E-cadherin
and up-regulate Vimentin expression. By evaluating the expression of 207 microRNAs
(miRNAs) in the 60 cell lines of the drug screening panel maintained by the Nation Cancer
Institute, we identified the miR-200 miRNA family as an extraordinary marker for cells that
express E-cadherin but lack expression of Vimentin. These findings were extended to …
(EMT) found during embryonic development, during which cells down-regulate E-cadherin
and up-regulate Vimentin expression. By evaluating the expression of 207 microRNAs
(miRNAs) in the 60 cell lines of the drug screening panel maintained by the Nation Cancer
Institute, we identified the miR-200 miRNA family as an extraordinary marker for cells that
express E-cadherin but lack expression of Vimentin. These findings were extended to …
[引用][C] The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
P Sm - Genes Dev., 2008 - cir.nii.ac.jp
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin
repressors ZEB1 and ZEB2 | CiNii Research … The miR-200 family determines the
epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 …
repressors ZEB1 and ZEB2 | CiNii Research … The miR-200 family determines the
epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 …
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