[HTML][HTML] The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis
F Soares, I Tattoli, MA Rahman, SJ Robertson… - Journal of Biological …, 2014 - ASBMB
NLRX1 is a mitochondrial Nod-like receptor (NLR) protein whose function remains
enigmatic. Here, we observed that NLRX1 expression was glucose-regulated and blunted
by SV40 transformation. In transformed but not primary murine embryonic fibroblasts,
NLRX1 expression mediated resistance to an extrinsic apoptotic signal, whereas conferring
susceptibility to intrinsic apoptotic signals, such as glycolysis inhibition, increased cytosolic
calcium and endoplasmic reticulum stress. In a murine model of colorectal cancer induced …
enigmatic. Here, we observed that NLRX1 expression was glucose-regulated and blunted
by SV40 transformation. In transformed but not primary murine embryonic fibroblasts,
NLRX1 expression mediated resistance to an extrinsic apoptotic signal, whereas conferring
susceptibility to intrinsic apoptotic signals, such as glycolysis inhibition, increased cytosolic
calcium and endoplasmic reticulum stress. In a murine model of colorectal cancer induced …
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