Background Neoepitopes derived from tumor-specific somatic mutations are promising
targets for immunotherapy in childhood cancers. However, the potential for such therapies in
targeting these epitopes remains uncertain due to a lack of knowledge of the neoepitope
landscape in childhood cancer. Studies to date have focused primarily on missense
mutations without exploring gene fusions, which are a major class of oncogenic drivers in
pediatric cancer. Methods We developed an analytical workflow for identification of putative …