The neuropeptide PACAP attenuates β-amyloid (1–42)-induced toxicity in PC12 cells
S Onoue, K Endo, K Ohshima, T Yajima, K Kashimoto - Peptides, 2002 - Elsevier
Pituitary adenylate cyclase activating polypeptide (PACAP) modulates neurotransmission in
the central and peripheral nervous systems. In vitro and in vivo studies have shown the
protective effects of PACAP against neuronal damage induced by ischemia and agonists of
NMDA-type glutamate receptors. Here, we demonstrated that PACAP also protected against
neuronal toxicity induced by β-amyloid (Aβ) peptide, aggregation of which is a causative
factor for Alzheimer's disease. PACAP (10− 9M) rescued 80% of decreased cell viability and …
the central and peripheral nervous systems. In vitro and in vivo studies have shown the
protective effects of PACAP against neuronal damage induced by ischemia and agonists of
NMDA-type glutamate receptors. Here, we demonstrated that PACAP also protected against
neuronal toxicity induced by β-amyloid (Aβ) peptide, aggregation of which is a causative
factor for Alzheimer's disease. PACAP (10− 9M) rescued 80% of decreased cell viability and …
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