The p12 subunit of human polymerase δ uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA)
A Gonzalez-Magaña, AI De Opakua… - Journal of biological …, 2019 - ASBMB
Human DNA polymerase δ is essential for DNA replication and acts in conjunction with the
processivity factor proliferating cell nuclear antigen (PCNA). In addition to its catalytic
subunit (p125), pol δ comprises three regulatory subunits (p50, p68, and p12). PCNA
interacts with all of these subunits, but only the interaction with p68 has been structurally
characterized. Here, we report solution NMR–, isothermal calorimetry–, and X-ray
crystallography–based analyses of the p12–PCNA interaction, which takes part in the …
processivity factor proliferating cell nuclear antigen (PCNA). In addition to its catalytic
subunit (p125), pol δ comprises three regulatory subunits (p50, p68, and p12). PCNA
interacts with all of these subunits, but only the interaction with p68 has been structurally
characterized. Here, we report solution NMR–, isothermal calorimetry–, and X-ray
crystallography–based analyses of the p12–PCNA interaction, which takes part in the …
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