The paper explores the use of a “digital twin model” applied to the case study of a residential district, and organized as a three-dimensional data system able to participate to the intelligent optimization and automation of the energy management and efficiency of the building system. The case study focuses on the area called Rinascimento III in Rome, consisting of 16 eight-floor building hosting 216 apartment units with an overall percentage of self-renewable energy produced by the building complex equal to 70%. This already quite high percentage means that the building complex can be defined as a Near Zero Energy Building (NZEB), i.e. a building that has a very high energy performance, and the nearly-zero or very low amount of energy required should be covered to a very significant extent by energy from renewable sources, including energy from renewable source produced on-site or nearby.