With the aim of investigating the relationship between psychological empowerment (meaningfulness, competence, influence, self-determination, and trust) and entrepreneurship, 189 personnel from Fars Payame Noor University were chosen through class sampling and answered to the questionnaires of entrepreneurship and psychological empowerment. Generally, results of regression analysis showed that psychological empowerment is able to predict entrepreneurship. Among the psychological empowerment, meaningfulness and competence respectively explained the most (R²=0.37) and the least (R²=0.11) amount of entrepreneurship variance.