… The toxicity of autophagy defects in liver is partly ameliorated by deficiency … the autophagy
substrate p62, but this is not the case for the brain (5, 6). The recent revelation that autophagy …

… , such as in tumor suppression and promotion, cancer-drug … the interaction between
autophagy and cancer stem-cells. Finally, we discuss autophagy as a therapeutic target in cancer …

… situations in which autophagy can either promote or inhibit tumorigenesis (Kimmelman
2011). The most likely explanation is that the role of autophagy in cancer is dynamic. Although …

… This supports the role for autophagy in protecting the genome … the role of tumour cell
metabolism in response to stress, the rational ability to modulate the autophagy pathway in cancer …

… Analysis of autophagic signaling may identify novel therapeutic … the multiple roles played
by autophagy in tumor biology, including its emergence as a therapeutic target for both cancer …

… upregulate autophagy as a response to cancer … autophagy can enhance the killing of tumor
cells after treatment. Interestingly, the FK506-binding protein 51 plays a role in the autophagy-…

… kills cancer cells or protects them from unfavourable … the accumulating data about the
role of autophagy in cancer, and discusses the attractive prospect of manipulating autophagic …

… autophagy can be either cancer-promoting or inhibiting. Here, we summarize the effects of
autophagy on cancer … We also discuss the efforts to pharmacologically target autophagy in the …

… that can control the formation and existence of a cancer cell, … about the relationship between
autophagy and cancer (4,6). … the molecular control of autophagy and to delineate how the …

… targets, the role of autophagy in physiology and in the … Our understanding of the role of
autophagy in physiology and … of the role of autophagy in different contexts could lead to the …