The role of FoxA2 transcription factor as potential regulator of articular cartilage hypertrophy and OA progression
Purpose: The proposed studies are anticipated to establish whether FoxA2 is a potential
target for the treatment of OA, and also to provide insights into mechanisms underlying OA
initiation. Methods: The following mouse lines were used: FoxA2 flox/flox, FoxA3-/-, TREtight-
FoxA2, and Prg4 CreERt2-GFP mice. Results: We evaluated the expression of FoxA2 in both
healthy and OA cartilage using FoxA2 IRES-CreERT2/+ Tomato reporter mice. In healthy
articular cartilage, the majority of cells positive for FoxA2 expression (red) are located on the …
target for the treatment of OA, and also to provide insights into mechanisms underlying OA
initiation. Methods: The following mouse lines were used: FoxA2 flox/flox, FoxA3-/-, TREtight-
FoxA2, and Prg4 CreERt2-GFP mice. Results: We evaluated the expression of FoxA2 in both
healthy and OA cartilage using FoxA2 IRES-CreERT2/+ Tomato reporter mice. In healthy
articular cartilage, the majority of cells positive for FoxA2 expression (red) are located on the …
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