过去一年中添加的文章，按日期排序
TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing
C Li, L Wang, W Xie, E Chen, Y Chen, H Li, D Can… - Science …, 2024 - science.org
13 天前 - … has a significant impact on the pathogenesis of Alzheimer’s disease (AD). We found
… up-regulation of the bile acid receptor Takeda G protein-coupled receptor (TGR5), which is …
… up-regulation of the bile acid receptor Takeda G protein-coupled receptor (TGR5), which is …
Amyloid-beta pathology–induced nanoscale synaptic disruption: the case of the GABAB–GIRK assembly
14 天前 - … the gammaaminobutyric acid G protein-coupled receptor type B (GABAB receptor)
in … –protein interactions are those between G protein-coupled receptors (GPCRs) and their …
in … –protein interactions are those between G protein-coupled receptors (GPCRs) and their …
Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by Aβ1–42 in Mice
YS Liang, Y Yang, Z Jie, X Kang, H Xu, HW Zhang… - Molecular …, 2024 - Springer
26 天前 - … G protein-coupled receptor 35 (GPR35) is expressed in the brain and is involved
in metabolic stresses. However, the role of GPR35 in AD pathogenesis remains unknown. …
in metabolic stresses. However, the role of GPR35 in AD pathogenesis remains unknown. …
Anti-Inflammatory Effects of GPR55 Agonists and Antagonists in LPS-Treated BV2 Microglial Cells
L Sun, M Apweiler, C Normann, CW Grathwol, T Hurrle… - Pharmaceuticals, 2024 - mdpi.com
48 天前 - … G-protein-coupled receptors (GPCRs) have been identified as an important class of
receptors in the pathogenesis of psychiatric disorders… GPR55, a receptor considered part of …
receptors in the pathogenesis of psychiatric disorders… GPR55, a receptor considered part of …
Cannabinoid and Orexigenic Systems Interplay as a New Focus of Research in Alzheimer's Disease
57 天前 - … of the disease pathophysiology and to find potential therapeutic interventions. In
this regard, G protein-coupled receptors (… diseases such as AD. Orexin and cannabinoid …
this regard, G protein-coupled receptors (… diseases such as AD. Orexin and cannabinoid …
… of Selective Ligands and Pharmacological Tools Targeting Caspase-2, Histamine H₂ Receptors, and orphan GPR3 for the Treatment of Neurodegenerative Diseases
MN Bresinsky - 2024 - epub.uni-regensburg.de
68 天前 - … Even though great efforts have been made in the last decades to understand the
pathology of Alzheimer's disease and to discover effective and safe drugs, there is still a long …
pathology of Alzheimer's disease and to discover effective and safe drugs, there is still a long …
Interaction of Tau with G-Protein-Coupled Purinergic P2Y12 Receptor by Molecular Docking and Molecular Dynamic Simulation
H Chidambaram, SE Desale… - Tau Protein: Methods and …, 2024 - Springer
112 天前 - … Under pathological conditions, Tau interacts with several G-protein-coupled
receptors (GPCRs), which undergoes either receptor signaling or desensitization followed by …
receptors (GPCRs), which undergoes either receptor signaling or desensitization followed by …
Up-regulation of GPR139 in the medial septum ameliorates cognitive impairment in two mouse models of Alzheimer's disease
R Mu, X Hou, Q Liu, W Wang, C Qin, H Li - International …, 2024 - Elsevier
127 天前 - … G-protein coupled receptors (GPCRs) constitute the largest class of cell surface …
node in cognition and potentially provides insight into the pathogenesis of Alzheimer’s disease. …
node in cognition and potentially provides insight into the pathogenesis of Alzheimer’s disease. …
Network analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimer's, and diabetes
140 天前 - … Lysophosphatidic acid receptors (LPARs), belonging to the G protein-coupled
receptor … of LPAR also plays a role in diabetes (DM) pathology. Intraperitoneal administration of …
receptor … of LPAR also plays a role in diabetes (DM) pathology. Intraperitoneal administration of …
A106: Aerobic Exercise Modulates GPCR/cAMP/PKA Signaling Pathway and Complement-Microglia Axis to Prevent Synaptic Loss in APP/PS1 Mice
J Yang, S Yuan, Y Jian, Y Lei… - … Activity and Health, 2024 - scholarworks.boisestate.edu
149 天前 - … may unveil crucial insights into early pathological changes, offering … Alzheimer's
disease (AD). This effect may be attributed to the regulation of the G protein-coupled receptors (…
disease (AD). This effect may be attributed to the regulation of the G protein-coupled receptors (…