The role of alcohol dehydrogenase in the metabolism of the colon carcinogen methylazoxymethanol
DA Delker, SJ McKnight III, DW Rosenberg - Toxicological Sciences, 1998 - Elsevier
The aim of this study was to determine whether the cytosolic enzyme alcohol
dehydrogenase (ADH) activates methylazoxymethanol (MAM) in the mouse colon and
whether differential tumor susceptibility in the mouse is dependent, in part, on strain-related
differences in MAM metabolism by ADH. Liver and colon cytosols were isolated from 7-week-
old male tumor-susceptible (SWR/J) and-resistant (AKR/J) mice. Minimal reduction of NAD+
was found in colon cytosols from AKR/J mice at the highest concentration (2 mM) of MAM …
dehydrogenase (ADH) activates methylazoxymethanol (MAM) in the mouse colon and
whether differential tumor susceptibility in the mouse is dependent, in part, on strain-related
differences in MAM metabolism by ADH. Liver and colon cytosols were isolated from 7-week-
old male tumor-susceptible (SWR/J) and-resistant (AKR/J) mice. Minimal reduction of NAD+
was found in colon cytosols from AKR/J mice at the highest concentration (2 mM) of MAM …
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