Accumulation of unfolded proteins in the endoplasmic reticulum initiates intracellular
signaling termed the unfolded protein response (UPR). Although Xbp1 serves as a pivotal
transcription factor for the UPR, the physiological role of UPR signaling and Xbp1 in the
central nervous system remains to be elucidated. Here, we show that Xbp1 mRNA was
highly expressed during neurodevelopment and activated Xbp1 protein was distributed
throughout developing neurons, including neurites. The isolated neurite culture system and …