The role of passive normalization, voltage-gated channels and synaptic scaling in site-independence of somatic EPSP amplitude in CA1 pyramidal neurons
K Moradi, G Kaka, S Gharibzadeh - Neuroscience Research, 2012 - Elsevier
Dendrites of pyramidal cells receive excitatory synapses and attenuate them toward the
soma.“Synaptic attenuation” in CA1 pyramidal cells is compensated with “synaptic scaling”
to make the amplitude of somatically recorded EPSPs site-independent. Recent studies,
however, show that voltage-gated channels and passive properties of dendrites have impact
on the sub-threshold EPSP amplitude. In this study, we want to evaluate the relative
importance of three factors on site-independence of somatic EPSP amplitude:(1)“passive …
soma.“Synaptic attenuation” in CA1 pyramidal cells is compensated with “synaptic scaling”
to make the amplitude of somatically recorded EPSPs site-independent. Recent studies,
however, show that voltage-gated channels and passive properties of dendrites have impact
on the sub-threshold EPSP amplitude. In this study, we want to evaluate the relative
importance of three factors on site-independence of somatic EPSP amplitude:(1)“passive …