The role of substance abuse in HIV disease progression: reconciling differences from laboratory and epidemiologic investigations
Clinical Infectious Diseases, 2005•academic.oup.com
From the onset of the HIV/AIDS epidemic, the use of licit and illicit drugs has been
investigated for its potential impact on HIV disease progression. Findings from a large
number of laboratory-based studies indicate that drug abuse may exacerbate HIV disease
progression; however, epidemiological studies have shown mixed results. This article
presents a review of findings from both laboratory-based and epidemiologic investigations.
In addition, we provide a careful evaluation of methodological strengths and limitations …
investigated for its potential impact on HIV disease progression. Findings from a large
number of laboratory-based studies indicate that drug abuse may exacerbate HIV disease
progression; however, epidemiological studies have shown mixed results. This article
presents a review of findings from both laboratory-based and epidemiologic investigations.
In addition, we provide a careful evaluation of methodological strengths and limitations …
Abstract
From the onset of the HIV/AIDS epidemic, the use of licit and illicit drugs has been investigated for its potential impact on HIV disease progression. Findings from a large number of laboratory-based studies indicate that drug abuse may exacerbate HIV disease progression; however, epidemiological studies have shown mixed results. This article presents a review of findings from both laboratory-based and epidemiologic investigations. In addition, we provide a careful evaluation of methodological strengths and limitations inherent to both study designs in order to provide a more nuanced understanding of how these findings may complement one another.
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