The ubiquitin code

D Komander, M Rape - Annual review of biochemistry, 2012 - annualreviews.org
… role of ubiquitylation in regulating localization serves as a final example for the diverse
functions of the ubiquitin code. Ubiquitin-dependent changes in localization had originally been …

The ubiquitin code in the ubiquitin-proteasome system and autophagy

YT Kwon, A Ciechanover - Trends in biochemical sciences, 2017 - cell.com
The diverse ways to assemble ubiquitin chains provide … the complexity of the ubiquitin
code, with an emphasis on the … ) in the ubiquitin-proteasome system (UPS) and the autophagy-…

An expanded lexicon for the ubiquitin code

I Dikic, BA Schulman - Nature reviews Molecular cell biology, 2023 - nature.com
… summarizes the current knowledge of the ubiquitin code, including unprecedented ubiquitin
… by which bacteria and viruses reconfigure the ubiquitin code to promote infection. We also …

The increasing complexity of the ubiquitin code

R Yau, M Rape - Nature cell biology, 2016 - nature.com
… same: distinct types of modification can trigger specific cellular responses that are at the
heart of … of the ubiquitin code in all its complexity — the temporal and structural dynamics, the

Expanding the ubiquitin code through post‐translational modification

L Herhaus, I Dikic - EMBO reports, 2015 - embopress.org
… This review summarizes the current understanding of the regulation of Ub by the well‐studied
PTM phosphorylation and also by the less well‐understood acetylation (see Box 1) and …

Ubiquitin code assembly and disassembly

C Heride, S Urbé, MJ Clague - Current Biology, 2014 - cell.com
… All of the intermediates in the enzymatic activation of the ubiquitin carboxyl terminus are
thioesters, which can form adventitious adducts by thiol or amine modification. In vitro data have …

Using ubiquitin binders to decipher the ubiquitin code

M Mattern, J Sutherland, K Kadimisetty, R Barrio… - Trends in biochemical …, 2019 - cell.com
… of the Ub code is performed by factors that recognize Ub/UbL chains and connect the
affinity-based approaches, TUBEs will contribute to unraveling the secrets of the Ub code. …

The ubiquitination code: a signalling problem

T Woelk, S Sigismund, L Penengo, S Polo - Cell division, 2007 - Springer
… and form a central question in the field. … light on the Ub code and that regard the topology
of Ub signals, the identification of new UBDs and the regulation of the critical enzymes of the

[PDF][PDF] Cracking the ubiquitin code: the ubiquitin toolbox

MPC Mulder, KF Witting, H Ovaa - Current issues in molecular …, 2020 - researchgate.net
… by the ubiquitination of the tumour suppressor p53 by the E3 … modulate the biological
consequence of Ubiquitination, Ub … the N-terminal methionine (Met1-linked ubiquitination) or any …

[HTML][HTML] Defining an embedded code for protein ubiquitination

T Jadhav, MW Wooten - Journal of proteomics & bioinformatics, 2009 - ncbi.nlm.nih.gov
… It has been more than 30 years since the initial report of the discovery of ubiquitin as an 8.5
… And still, protein modification by covalent conjugation of the ubiquitin molecule is one of the