… acne by the US Food and Drug Administration (FDA) in 1982. To date the efficacy of isotretinoin
has … two decades later isotretinoin remains the most clinically effective anti-acne therapy, …

… be a consistent observation in the vast majority of treated patients. 2, 24–36 In addition to
severe nodular acne, the use of ISO within the dermatology community for acne has included …

… studies, using the terms isotretinoin and acne, up to March 2020. After the selection of the
studies addressing critically themes on the use of oral isotretinoin for acne, more specifically …

… dependence on isotretinoin's effects rather than the extent of their acne. 34 Both the mid- and
… good immediate and long-term efficacy at the end of 4 months of treatment. Nevertheless, …

… Other recent concerns over the potential development of mood … the use of isotretinoin and
of the necessary pretreatment evaluation and further monitoring. As used in this document, the …

… While the use of isotretinoin has revolutionized the treatment of acne vulgaris, isotretinoin
is … We review the evidence underlying the use of isotretinoin for a variety of dermatological …

… isotretinoin with the risk of depressive disorders (RR=1.15, 95% CI 0.60 to 2.21, p=0.14). The
association of the use of isotretinoin with the … of the use of isotretinoin in patients with acne …

… acne; consequently, the type of acne treated with isotretinoin is not … 2000, the proportion of
isotretinoin treatment for severe acne … the proportion of treatment for mild and moderate acne …

… the treatment of severe refractory nodulocystic acne. The pharmacological profile of isotretinoin
… possibility of long term spinal or skeletal bone toxicity may restrict the use of isotretinoin …

… The use of lower doses of isotretinoin during the first 3–4 … to minimize the incidence of side
effects in relation to alteration of the … The dose can be gradually increased during the following …