Despite considerable progress in the management of ischaemic cardiovascular disease
during the past three decades, there remains a significant population of patients who are not
served well by current treatment approaches. Stimulating revascularization in ischaemic
regions is an attractive novel therapeutic strategy, and several angiogenic agents
anticipated to have the potential to achieve this goal have been clinically evaluated in recent
years. However, as yet none have shown sufficient efficacy to be approved. Here, we …

Atherosclerotic disease of the arteries is a major cause of coronary artery disease,
peripheral vascular disease and stroke. Some patients are however not candidate for the
standard treatment of angioplasty or bypass surgery. Hence there is tremendous enthusiasm
for the utilization of angiogenesis as a therapeutic modality for atherosclerotic arterial
disease. This augmentation of physiological neo-vascularization in cardiovascular disease
can be achieved through different pathways. In this article we are reviewing the Use of Gene …